One of film's busiest actors, she will soon be seen starring in Charlie Kaufman's Synecdoche, New York, with Philip Seymour Hoffman; Joe Wright's The Soloist, with Jamie Foxx; Spike Jonze's Where the Wild Things Are; Michael Winterbottom's Genova; and an untitled new film from writer/director Nicole Holofcener.

Ms. Keener's portrayal of To Kill A Mockingbird author Harper Lee in Bennett Miller's Capote, in which she starred opposite Philip Seymour Hoffman in his Academy Award-winning performance, garnered her Academy Award, BAFTA and Screen Actors Guild Award nominations, as well as the Toronto Film Critics Association's award for Best Supporting Actress. She was also honored for the performance, in tandem with her work in three other films that same year - Rebecca Miller's The Ballad of Jack and Rose, Sydney Pollack's The Interpreter, and Judd Apatow's The 40-Year-Old Virgin - by the Los Angeles Film Critics Association.

Her first Academy Award nomination came for her performance in Spike Jonze's Being John Malkovich, which also earned her the New York Film Critics Circle's award for Best Supporting Actress and Golden Globe and Screen Actors Guild Award nominations.

Ms. Keener has been nominated three times for an Independent Spirit Award, for Nicole Holofcener's Walking and Talking and Lovely & Amazing, and for Tom DiCillo's Johnny Suede. She has since also starred for the latter director in Living in Oblivion, Box of Moonlight, and The Real Blonde.

He many other films include Nicole Holofcener's Friends with Money; Neil LaBute's Your Friends & Neighbors; Steven Soderbergh's Out of Sight and Full Frontal; Michael Hacker's The Destiny of Marty Fine; Tommy O'Haver's An American Crime, with Ellen Page; Barry Levinson's What Just Happened?, which world-premiered at the 2008 Sundance Film Festival; and David O. Russell's upcoming Nailed.

For television, Ms. Keener has made notable appearances in the telefilm If These Walls Could Talk (in the segment directed by Cher) and on Seinfeld. On stage, her credits include starring opposite Edward Norton in the Signature Theater Company's critically acclaimed off-Broadway revival of Lanford Wilson's Burn This.